grapefruit
Fruit
Is grapefruit high in tyramine?
Is grapefruit high or low in tyramine? See its exact rating, how much counts as a portion, and its FODMAP, salicylate, oxalate and diet compatibility in one place.
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Sensitivity notes
Why tyramine food checker matters
Tyramine is an amino acid that forms when proteins break down. It's found in aged, fermented, or spoiled foods. For people taking MAO inhibitors or those with tyramine sensitivity, it can cause headaches, elevated blood pressure, and other reactions.
- Choose fresh over aged, fermented, or preserved foods
- Eat protein foods fresh and store properly
- Be especially careful if taking MAO inhibitor medications
- Common high-tyramine foods include aged cheese, cured meats, and soy sauce
- Ripeness affects tyramine - choose less ripe fruits
Sensitivities
What grapefruit contains
FODMAPs
Histamine & Amines
Plant compounds
Irritants
Additives
Allergens
Diet fit
Where grapefruit fits
Therapeutic diets
Lifestyle diets
Religious diets
What to know about grapefruit
Grapefruit is more than a tart breakfast citrus. It is very high in oxalate, high in salicylates, and acts as a histamine liberator, an unusual triple for a fruit, and it is high FODMAP by volume with a moderate excess-fructose load. On top of that trigger profile, grapefruit is famous for interacting with dozens of prescription medications, an effect most everyday citrus like oranges and clementines does not share.
Watch for
- Very high in oxalate, the most oxalate-heavy fruit in this group, which matters if you form calcium-oxalate kidney stones
- Histamine liberator and high in salicylates, so it can set off flushing, itching, headaches or a runny nose in people sensitive to either
- High FODMAP by volume, with a moderate excess-fructose load, so large servings or grapefruit juice can bring on bloating and loose stools
- Contains furanocoumarins that block the CYP3A4 enzyme, so grapefruit can raise blood levels of many statins, blood-pressure and other drugs to unsafe levels; check with a pharmacist
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Tyramine Guide
Everything you need to know about tyramine sensitivity and smart food choices.
Tyramine is an amino acid that forms when proteins break down. It's found in aged, fermented, or spoiled foods. For people taking MAO inhibitors or those with tyramine sensitivity, it can cause headaches, elevated blood pressure, and other reactions.
Sensitivity varies widely. What triggers one person may be fine for another. Track your reactions to find your personal threshold.
These foods are generally well-tolerated for Tyramine sensitivity:
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These foods are high in tyramine and may trigger symptoms:
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If you're sensitive to Tyramine, consider these strategies:
- 1Choose fresh over aged, fermented, or preserved foods
- 2Eat protein foods fresh and store properly
- 3Be especially careful if taking MAO inhibitor medications
- 4Common high-tyramine foods include aged cheese, cured meats, and soy sauce
- 5Ripeness affects tyramine - choose less ripe fruits
Pro tip: Keep a food diary to track your reactions. The Triggerbites app makes this easy with automatic pattern detection.
Want personalized tracking?
Download Triggerbites to log meals, track symptoms, and discover your unique triggers.
Get the AppFAQ
Is grapefruit high in Tyramine?
Tyramine: low signal for most people.
Can I still eat grapefruit if I'm sensitive to Tyramine?
Usually fine in normal portions.
What else should I check?
Check Oxalates, Histamine Liberators, and FODMAPs next for a fuller picture.