black seed oil
Oils & Fats
Is black seed oil high in tyramine?
Is black seed oil high or low in tyramine? See its exact rating, how much counts as a portion, and its FODMAP, salicylate, oxalate and diet compatibility in one place.
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Compare black seed oil across criteria
Sensitivity notes
Why tyramine food checker matters
Tyramine is an amino acid that forms when proteins break down. It's found in aged, fermented, or spoiled foods. For people taking MAO inhibitors or those with tyramine sensitivity, it can cause headaches, elevated blood pressure, and other reactions.
- Choose fresh over aged, fermented, or preserved foods
- Eat protein foods fresh and store properly
- Be especially careful if taking MAO inhibitor medications
- Common high-tyramine foods include aged cheese, cured meats, and soy sauce
- Ripeness affects tyramine - choose less ripe fruits
Sensitivities
What black seed oil contains
FODMAPs
Histamine & Amines
Plant compounds
Irritants
Additives
Allergens
Diet fit
Where black seed oil fits
Therapeutic diets
Lifestyle diets
Religious diets
What to know about black seed oil
Black seed oil, pressed from Nigella sativa, is one of the few things in this database that grades A on every single trigger column: histamine, histamine liberation, tyramine, salicylates, oxalate, nickel, sulfites, nitrites, free glutamate, lectins, gluten, lactose, dairy protein and all five FODMAP groups. It is worth noting that the whole seed grades D for salicylates while the oil grades A, because those phenolics stay with the solids in the press cake. The honest caveat on this page is not a food chemical at all. Black seed oil is bought as a supplement rather than as a cooking fat, its active compound thymoquinone has measurable effects on drug-metabolising enzymes and on blood sugar and blood pressure, and the dose in a daily spoonful is nothing like the dose in a salad dressing.
Watch for
- Thymoquinone competitively inhibits CYP2C9, the enzyme that clears warfarin, and laboratory work also puts it on CYP2D6 and CYP3A4.Supplement level intakes (roughly a gram a day of oil or more) are the amounts flagged, not a pinch of the seed on bread. If you take warfarin, an anticoagulant, or anything with a narrow therapeutic window, this belongs on your medication list, not in your quiet supplement drawer
- It lowers blood glucose and blood pressure in trials, which is exactly why people take it, and exactly why it stacks with metformin, insulin or antihypertensives.Symptoms logged as a reaction (shakiness, lightheadedness on standing) can be that additive effect rather than an intolerance
- Topical use is where most reported reactions come from.Allergic contact dermatitis to black seed oil is well documented, including a case that progressed to eosinophilia with systemic symptoms and needed corticosteroids. If you use it on skin and eat it, you will not know which route caused a flare unless you separate them
- Potency is unregulated and thymoquinone content varies enormously between bottles, so two products at the same spoonful can be different doses.High doses have caused liver and kidney damage in animal studies, with human data lacking
- A tablespoon of any pressed oil is a fat load.Loose stools or reflux after a morning spoonful are usually the fat and the empty stomach, not a trigger chemical
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Tyramine Guide
Everything you need to know about tyramine sensitivity and smart food choices.
Tyramine is an amino acid that forms when proteins break down. It's found in aged, fermented, or spoiled foods. For people taking MAO inhibitors or those with tyramine sensitivity, it can cause headaches, elevated blood pressure, and other reactions.
Sensitivity varies widely. What triggers one person may be fine for another. Track your reactions to find your personal threshold.
These foods are generally well-tolerated for Tyramine sensitivity:
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These foods are high in tyramine and may trigger symptoms:
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If you're sensitive to Tyramine, consider these strategies:
- 1Choose fresh over aged, fermented, or preserved foods
- 2Eat protein foods fresh and store properly
- 3Be especially careful if taking MAO inhibitor medications
- 4Common high-tyramine foods include aged cheese, cured meats, and soy sauce
- 5Ripeness affects tyramine - choose less ripe fruits
Pro tip: Keep a food diary to track your reactions. The Triggerbites app makes this easy with automatic pattern detection.
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Get the AppFAQ
Is black seed oil high in Tyramine?
Tyramine: low signal for most people.
Can I still eat black seed oil if I'm sensitive to Tyramine?
Usually fine in normal portions.
What else should I check?
Check AIP, Gastroparesis Diet, and Reflux Diet next for a fuller picture.