tonic water
Beverages
Is tonic water high in tyramine?
Is tonic water high or low in tyramine? See its exact rating, how much counts as a portion, and its FODMAP, salicylate, oxalate and diet compatibility in one place.
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Compare tonic water across criteria
Sensitivity notes
Why tyramine food checker matters
Tyramine is an amino acid that forms when proteins break down. It's found in aged, fermented, or spoiled foods. For people taking MAO inhibitors or those with tyramine sensitivity, it can cause headaches, elevated blood pressure, and other reactions.
- Choose fresh over aged, fermented, or preserved foods
- Eat protein foods fresh and store properly
- Be especially careful if taking MAO inhibitor medications
- Common high-tyramine foods include aged cheese, cured meats, and soy sauce
- Ripeness affects tyramine - choose less ripe fruits
Sensitivities
What tonic water contains
FODMAPs
Histamine & Amines
Plant compounds
Irritants
Additives
Allergens
Diet fit
Where tonic water fits
Therapeutic diets
Lifestyle diets
Religious diets
What to know about tonic water
Tonic water is the odd one out in the drinks list, because its distinctive trigger is not alcohol at all. Tonic contains quinine, the bitter alkaloid extracted from cinchona bark that started life as an antimalarial and is still a prescription drug, and it is the reason a glass of tonic glows blue under UV light. Regulators cap how much can go into a beverage: the US limit is 83 parts per million, the EU limit is 100 milligrams per litre, and labels must declare that quinine is present. At those levels a mixer sits far below any therapeutic dose and most people never register it. A minority genuinely react, because quinine hypersensitivity is immune-mediated rather than dose-related, which means a sensitised person can respond to the amount in one glass. On the food-chemistry side tonic is otherwise clean, grading A for histamine, salicylates, gluten, dairy and sulfites, but regular tonic is still a sweetened soft drink and grades C for FODMAPs and C for excess fructose.
Watch for
- Quinine is a pharmacologically active compound, not just a bitter flavouring, which is why its level in beverages is capped by law (83 ppm in the US, 100 mg per litre in the EU) and why its presence has to be declared on the label.The classic overdose picture, cinchonism, means ringing ears, headache, nausea and blurred vision, and a normal mixer sits nowhere near it
- Quinine hypersensitivity does not follow dose.The medical literature contains cases of quinine-induced thrombocytopenia, showing up as unexplained bruising, pinpoint red spots or nosebleeds, traced back to tonic water and bitter lemon in people who were already sensitised. It is rare, but it is the reason the FDA has repeatedly warned against off-label prescription quinine
- Quinine interacts with other medicines, including anticoagulants, digoxin and drugs that affect heart rhythm.The amount in a mixer is usually far too small to matter, but it is worth mentioning to a prescriber if tonic is a daily habit
- Regular tonic is a soft drink first.It grades C for FODMAPs and C for excess fructose, and in the US it is commonly sweetened with high fructose corn syrup. Slimline and diet tonics cut the sugar but keep the quinine, so they solve the FODMAP question and not the quinine one
- Clean on the usual sensitivity axes: A for histamine, histamine liberation, salicylates, gluten, dairy protein, sulfites and glutamates.If a gin and tonic reliably bothers you, this page and the gin page are the two halves to test separately
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Tyramine Guide
Everything you need to know about tyramine sensitivity and smart food choices.
Tyramine is an amino acid that forms when proteins break down. It's found in aged, fermented, or spoiled foods. For people taking MAO inhibitors or those with tyramine sensitivity, it can cause headaches, elevated blood pressure, and other reactions.
Sensitivity varies widely. What triggers one person may be fine for another. Track your reactions to find your personal threshold.
These foods are generally well-tolerated for Tyramine sensitivity:
View all safe options
These foods are high in tyramine and may trigger symptoms:
View full list
If you're sensitive to Tyramine, consider these strategies:
- 1Choose fresh over aged, fermented, or preserved foods
- 2Eat protein foods fresh and store properly
- 3Be especially careful if taking MAO inhibitor medications
- 4Common high-tyramine foods include aged cheese, cured meats, and soy sauce
- 5Ripeness affects tyramine - choose less ripe fruits
Pro tip: Keep a food diary to track your reactions. The Triggerbites app makes this easy with automatic pattern detection.
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Get the AppFAQ
Is tonic water high in Tyramine?
Tyramine: low signal for most people.
Can I still eat tonic water if I'm sensitive to Tyramine?
Usually fine in normal portions.
What else should I check?
Check Acidic Foods, Inflammation, and AIP next for a fuller picture.